Mod+ Saturated Fat discussion for David

My feeling is that 9/11 was almost certainly not as portrayed - very murky - but I always tend to go for muddle theories rather than conspiracy theories. The problem with a simple conspiracy theory is that so many people would have to be in the know, and inevitably some would feel it was their patriotic duty to expose the truth.
David

The problem is that anyone with a clear thinking grasp of the evidence has no option but to make that choice- that is, for the much more plausible 'inside job' theory than the utter ridiculousness and implausibility, actually downright impossibility of the official Al Qaeda conspiracy theory.

I don't think anybody committing treason and involved in the mass murder of thousands of innocent people would feel it's their patriotic duty to expose the truth :D ... unless of course they like the idea of spending years alone in a small cell before being placed in an even smaller cell to convulse and suffocate to death in front of a small audience.
 
I wonder if some of the seeming discrepancy between a lot of real world experience and Linda's GQR's, is actually due to the experimenter effect.

It's not "real world experience". Both can be regarded as "real world experience". The difference is between real world experiences under conditions of low validity and under conditions of high validity. There's no need to postulate anything remarkable about the discrepancy. Your intuitive judgement performs so poorly under these low validity conditions that it would have been a big surprise if there wasn't a discrepancy.

An "experimenter effect" as an excuse doesn't help you out, as that it would take you further away from identifying a valid relationship between the drug and a side-effect in any case.

When people talk about the 'experimenter effect', they usually really mean that the experimenter was careless or even fraudulent, or if the experimenter was trying to debunk a result, that he/she didn't take enough care.

However Rupert Sheldrake takes the experimenter effect much more seriously - suggesting that experiments are actually influenced by the intentions or desires of the experimenters or others around them. He suspects even physics experiments may be subject to this effect.

Doesn't work. An experimenter effect of this type would mean we would be unable to have physical laws, build technology that works, or find valid relationships. But we have all those things. And we can actually watch experimenters in the act of engaging in questionable research practices (QRPs) in order to produce their positive effects (http://naturalismisuseful.blogspot.com/2014/03/hand-in-hand-with-flexibility-in.htm).

Think of an experiment to look at statin side effects. You randomly assign participants into two groups, and give one statin pills, and the other a placebo. This setup is rather reminiscent of some ψ experiments, where people are trying to influence the outcome of random events such as 2-slit quantum experiments by sheer mental force. There is certainly a powerful desire among the researchers to show that statins are not guilty, and suppose that that operates by shunting people who would show statin-like side effects into the placebo group (regardless of whether these would be real or incidental), and moving people who will not respond adversely to statins into the group that receive real statins!

Hundreds of individual researchers using skills which have never been demonstrated under these conditions. Yeah, that sounds plausible. :eek:

Here's the problem. Attributing your symptoms to a particular cause is taking place under conditions where it's very difficult to identify valid relationships. This has nothing to do with the research. Even if a study on statins had never been performed, it still wouldn't make your observations valid. It isn't the case that observations under poor conditions are valid until something better comes along to disprove them. They aren't valid regardless.

Likewise, there is possibly an even more powerful desire not to face the ridicule and fury of people if traditional diets that contained more saturated fat turn out to be better for us after 60 odd years of pushing the 'low fat' (i.e. low saturated fat) mantra.

It's not even remotely the big deal that you make it out to be. Doctors are constantly updating and changing advice, sometimes dramatically, on the basis of new and better information.

A existence of a genuine experimenter effect would blow RCT's out of the water!

Yeah. And since RCTs work, that should be a big clue against it.

This might explain why, people end up having so much difficulty with drugs that are supposed to be very well tolerated. It might also explain how it is that Prozac seemed at one time to perform much better than a placebo at relieving depression, and yet in a recent test performed no better than a placebo!

Clearly a real experimenter effect is effectively a manifestation of ψ, and it could be that when the statin scandal breaks, it won't just be another pharmaceutical horror story, but will reveal something deeper about our relationship with the physical world.

David

How is the "statin scandal" going to break without an ability to identify valid relationships?

Linda
 
How is the "statin scandal" going to break without an ability to identify valid relationships?

Linda

We will have to wait, but here is the latest example of a doctor deciding to personally come off statins and write about it.

http://www.telegraph.co.uk/health/10717431/Why-Ive-ditched-statins-for-good.html

He is a vascular surgeon, so he is possibly as qualified as you are to pass judgement on this matter as you are. What is undeniable, is that there is huge disagreement within medicine about the desirability of taking statins and the effects of saturated fats (read the whole article - both are relevant to his story).

I don't bet, but if I did, I'd wager a fair sum of money that the whole cholesterol/saturated fat/statin dogma is folding!

If it does, the interesting question will be what went wrong, given all those high quality studies pointing the other way.

There probably isn't much point in continuing this discussion - we will both have to watch what happens :)

David
 
We will have to wait,...

You haven't answered my question. What are we waiting for? What kind of information are we looking for which will show us the true relationship between statins and side-effects? What kind of information will show us the true relationship between saturated fats and heart disease? I'm really trying to understand where you are coming from, so it would be very helpful if you could give me an indication of what it is you are looking for which is different from the kinds of information we have already (or are in the process of collecting).

...but here is the latest example of a doctor deciding to personally come off statins and write about it.

http://www.telegraph.co.uk/health/10717431/Why-Ive-ditched-statins-for-good.html

He is a vascular surgeon, so he is possibly as qualified as you are to pass judgement on this matter as you are.

No he's not. He operates on varicose veins. He gives no indication in his writing that he has an evidence-based approach. And vascular surgeons of any type aren't the specialists who see patients for the purposes of reducing cardiovascular risk factors - internists, cardiologists, and endocrinologists are. He's just going on personal experience plus cherry-picking bits of research in order to support his opinion.

What you should be looking for are people with specific knowledge and experience who have looked at all the research and made a careful summary of what that research shows, as well as what areas are weak and would benefit from additional research. That is, the most qualified judgement comes from those whose opinion you have assiduously ignored:

http://www.nel.gov/topic.cfm?cat=2862

What is undeniable, is that there is huge disagreement within medicine about the desirability of taking statins and the effects of saturated fats (read the whole article - both are relevant to his story). I don't bet, but if I did, I'd wager a fair sum of money that the whole cholesterol/saturated fat/statin dogma is folding!

There's nothing unusual there. GPs are often slow adopters of evidence-based recommendations. This isn't specific to statins. They also took a long time to eventually come around to the idea of h. pylori as a significant cause of gastric ulcer. How come their reluctance on that point is used as a sign of closed-minded dogma ignoring the evidence, but their reluctance on this point represents the fight against close-minded dogma?

If it does, the interesting question will be what went wrong, given all those high quality studies pointing the other way.

Again, what kind of information are you looking for that trumps high quality studies?

There probably isn't much point in continuing this discussion - we will both have to watch what happens :)

David

Well, it would be really, really, really helpful to the discussion if you would answer my questions. Please? :D

Linda
 
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